Digestive System Tumours

Introduction to tumours of the digestive system

    Classification of neuroendocrine neoplasms of the digestive system

Tumours of the oesophagus

    Tumours of the oesophagus: Introduction

    Epithelial tumours

         Benign epithelial tumours and precursors
              Oesophageal squamous papilloma
              Barrett dysplasia
              Oesophageal squamous dysplasia
         Malignant epithelial tumours
              Adenocarcinoma of the oesophagus and oesophagogastric junction NOS
              Oesophageal adenoid cystic carcinoma
              Oesophageal adenosquamous and mucoepidermoid carcinomas
              Oesophageal squamous cell carcinoma NOS
              Oesophageal undifferentiated carcinoma
              Oesophageal neuroendocrine neoplasms

Tumours of the stomach

    Tumours of the stomach: Introduction

    Gastritis and metaplasia: precursors of gastric neoplasms

    Epithelial tumours

         Benign epithelial tumours and precursors
              Fundic gland polyps
              Gastric hyperplastic polyps
              Gastric dysplasia
              Intestinal-type gastric adenoma
              Foveolar-type adenoma
              Gastric pyloric gland adenoma
              Oxyntic gland adenoma
         Malignant epithelial tumours
              Gastric adenocarcinoma
              Gastric squamous cell carcinoma
              Gastric adenosquamous carcinoma
              Gastric undifferentiated carcinoma
              Gastroblastoma
              Gastric neuroendocrine neoplasms

Tumours of the small intestine and ampulla

    Tumours of the small intestine and ampulla: Introduction

    Epithelial tumours

         Benign epithelial tumours and precursors
              Non-ampullary adenoma
              Ampullary adenoma
         Malignant epithelial tumours
              Non-ampullary adenocarcinoma
              Ampullary adenocarcinoma
              Small intestinal and ampullary neuroendocrine neoplasms

Tumours of the appendix

    Tumours of the appendix: Introduction

    Epithelial tumours

              Appendiceal serrated lesions and polyps
              Appendiceal mucinous neoplasm
              Appendiceal adenocarcinoma
              Appendiceal goblet cell adenocarcinoma
              Appendiceal neuroendocrine neoplasms

Tumours of the colon and rectum

    Tumours of the colon and rectum: Introduction

    Epithelial tumours

         Benign epithelial tumours and precursors
              Colorectal serrated lesions and polyps
              Conventional colorectal adenoma
              Inflammatory bowel disease-associated dysplasia of the colorectum
         Malignant epithelial tumours
              Colorectal adenocarcinoma
              Colorectal neuroendocrine neoplasms

Tumours of the anal canal

    Tumours of the anal canal: Introduction

    Epithelial tumours

         Benign epithelial tumours and precursors
              Inflammatory cloacogenic polyp
              Anal condyloma
              Anal squamous dysplasia (intraepithelial neoplasia)
         Malignant epithelial tumours
              Anal squamous cell carcinoma
              Anal adenocarcinoma
              Anal neuroendocrine neoplasms

Tumours of the liver and intrahepatic bile ducts

    Tumours of the liver and intrahepatic bile ducts: Introduction

    Epithelial tumours

         Benign hepatocellular tumours
              Focal nodular hyperplasia of the liver
              Hepatocellular adenoma
         Malignant hepatocellular tumours and precursors
              Hepatocellular carcinoma
              Hepatoblastoma
         Benign biliary tumours and precursors
              Bile duct adenoma
              Biliary adenofibroma
              Biliary intraepithelial neoplasia (See chapter 9)
              Intraductal papillary neoplasm of the bile ducts (See chapter 9)
              Mucinous cystic neoplasm of the liver and biliary system
         Malignant biliary tumours
              Intrahepatic cholangiocarcinoma
         Combined hepatocellular-cholangiocarcinoma and undifferentiated primary liver carcinoma
         Hepatic neuroendocrine neoplasms

Tumours of the gallbladder and extrahepatic bile ducts

    Tumours of the gallbladder and extrahepatic bile ducts: Introduction

    Epithelial tumours

         Benign epithelial tumours and precursors
              Pyloric gland adenoma of the gallbladder
              Biliary intraepithelial neoplasia
              Intracholecystic papillary neoplasm (formerly Intracystic / intraductal papillary neoplasm)
              Intraductal papillary neoplasm of the bile ducts
         Malignant epithelial tumours
              Carcinoma of the gallbladder
              Carcinoma of the extrahepatic bile ducts
              Neuroendocrine neoplasms of the gallbladder and bile ducts

Tumours of the pancreas

    Tumours of the pancreas: Introduction

    Epithelial tumours

         Benign epithelial tumours and precursors
              Acinar cystic transformation of the pancreas
              Serous neoplasms of the pancreas
              Pancreatic intraepithelial neoplasia
              Pancreatic intraductal papillary mucinous neoplasm
              Pancreatic intraductal oncocytic papillary neoplasm
              Pancreatic intraductal tubulopapillary neoplasm
              Pancreatic mucinous cystic neoplasm
         Malignant epithelial tumours
              Pancreatic ductal adenocarcinoma
              Pancreatic acinar cell carcinoma
              Pancreatoblastoma
              Solid pseudopapillary neoplasm of the pancreas
         Pancreatic neuroendocrine neoplasms
              Pancreatic neuroendocrine neoplasms: Introduction
              Non-functioning pancreatic neuroendocrine tumours
              Functioning pancreatic neuroendocrine tumours
                   Insulinoma
                   Gastrinoma
                   VIPoma
                   Glucagonoma
                   Somatostatinoma
                   ACTH-producing neuroendocrine tumour
                   Serotonin-producing neuroendocrine tumour
              Pancreatic neuroendocrine carcinoma
              Pancreatic MiNENs

Haematolymphoid tumours of the digestive system

    Haematolymphoid tumours of the digestive system: Introduction

    Haematolymphoid tumours

         Site-specific haematolymphoid tumours
              Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) involving the digestive tract
              Duodenal-type follicular lymphoma
              Enteropathy-associated T-cell lymphoma
              Monomorphic epitheliotropic intestinal T-cell lymphoma
              Intestinal T-cell lymphoma NOS
              Indolent T-cell lymphoproliferative disorder of the GI tract
              Hepatosplenic T-cell lymphoma
              EBV+ inflammatory follicular dendritic cell sarcoma of the digestive tract
         Haematolymphoid tumours occurring with some frequency in the digestive system
              Diffuse large B-cell lymphoma
              Follicular lymphoma
              Mantle cell lymphoma
              Burkitt lymphoma
              Plasmablastic lymphoma
              Posttransplant lymphoproliferative disorders
              Extranodal NK/T-cell lymphoma
              Systemic mastocytosis
              Langerhans cell histiocytosis
              Follicular dendritic cell sarcoma
              Histiocytic sarcoma

Mesenchymal tumours of the digestive system

    Mesenchymal tumours of the digestive system: Introduction

    Mesenchymal tumours

         Gastrointestinal stromal tumour
              Gastrointestinal stromal tumour
         Adipose tissue and (myo)fibroblastic tumours
              Inflammatory myofibroblastic tumour
              Desmoid fibromatosis
              Solitary fibrous tumour
              Lipoma
              Inflammatory fibroid polyp
              Plexiform fibromyxoma
         Smooth muscle and skeletal muscle tumours
              Leiomyoma
              Leiomyosarcoma
              Rhabdomyosarcoma
         Vascular and perivascular tumours
              Haemangioma
              Epithelioid haemangioendothelioma (prev Vascular Tumours in Liver)
              Kaposi sarcoma
              Angiosarcoma
              Glomus tumour
              Lymphangioma and lymphangiomatosis
         Neural tumours
              Schwannoma
              Granular cell tumour
              Perineurioma
              Ganglioneuroma and ganglioneuromatosis
         Tumours of uncertain differentiation
              PEComa, including angiomyolipoma
              Mesenchymal hamartoma of the liver
              Calcifying nested stromal-epithelial tumour of the liver
              Synovial sarcoma
              Gastrointestinal clear cell sarcoma / malignant gastrointestinal neuroectodermal tumour
              Embryonal sarcoma of the liver

Other tumours of the digestive system

         Other tumours of the digestive system
              Mucosal melanoma of the digestive system
              Germ cell tumours of the digestive system
              Digestive system metastases

Genetic tumour syndromes of the digestive system

    Genetic tumour syndromes of the digestive system: Introduction

    Genetics

         Genetic tumour syndromes of the digestive system
              Lynch syndrome
              Familial adenomatous polyposis 1
              GAPPS and other fundic gland polyposes
              Other adenomatous polyposes
              Serrated polyposis
              Hereditary diffuse gastric cancer
              Familial pancreatic cancer
              Juvenile polyposis syndrome
              Peutz-Jeghers syndrome
              Cowden syndrome
              Other genetic tumour syndromes