Female Genital Tumours

Tumours of the ovary

    Tumours of the ovary: Introduction

    Serous tumours

         Benign serous tumours
              Serous cystadenoma, adenofibroma, and surface papilloma of the ovary
         Borderline serous tumours
              Serous borderline tumour of the ovary
         Malignant serous tumours
              Low-grade serous carcinoma of the ovary
              High-grade serous carcinoma of the ovary

    Mucinous tumours

         Benign mucinous tumours
              Mucinous cystadenoma and adenofibroma
         Borderline mucinous tumours
              Mucinous borderline tumour
         Malignant mucinous tumours
              Mucinous carcinoma of the ovary

    Endometrioid tumours

         Benign endometrioid tumours
              Endometrioid cystadenoma and adenofibroma
         Borderline endometrioid tumours
              Endometrioid borderline tumour
         Malignant endometrioid tumours
              Endometrioid carcinoma of the ovary

    Clear cell tumours

         Benign clear cell tumours
              Clear cell cystadenoma and adenofibroma
         Borderline clear cell tumours
              Clear cell borderline tumour
         Malignant clear cell tumours
              Clear cell carcinoma of the ovary

    Seromucinous tumours

         Benign seromucinous tumours
              Seromucinous cystadenoma and adenofibroma
         Borderline seromucinous tumours
              Seromucinous borderline tumour
         Malignant seromucinous tumours
              Seromucinous carcinoma

    Brenner tumours

         Benign Brenner tumours
              Brenner tumour
         Borderline Brenner tumours
              Borderline Brenner tumour
         Malignant Brenner tumours
              Malignant Brenner tumour

    Other carcinomas

              Mesonephric-like adenocarcinoma
              Undifferentiated and dedifferentiated carcinomas of the ovary
              Carcinosarcoma of the ovary
              Mixed carcinoma of the ovary

    Mesenchymal tumours

              Endometrioid stromal sarcoma of the ovary
              Smooth muscle tumours of the ovary
              Ovarian myxoma
              Other ovarian mesenchymal tumours

    Mixed epithelial and mesenchymal tumours

         Mixed malignant epithelial and mesenchymal tumours
              Adenosarcoma of the ovary

    Sex cord-stromal tumours

         Pure stromal tumours
              Ovarian fibroma
              Thecoma
              Luteinized thecoma associated with sclerosing peritonitis
              Sclerosing stromal tumour
              Microcystic stromal tumour
              Signet-ring stromal tumour
              Leydig cell tumour
              Steroid cell tumour
              Ovarian fibrosarcoma
         Pure sex cord tumours
              Adult granulosa cell tumour
              Juvenile granulosa cell tumour
              Sertoli cell tumour
              Sex cord tumour with annular tubules
         Mixed sex cord-stromal tumours
              Sertoli-Leydig cell tumour
              Sex cord-stromal tumour NOS
              Gynandroblastoma

    Germ cell tumours

              Mature teratoma of the ovary
              Immature teratoma of the ovary
              Dysgerminoma
              Yolk sac tumour
              Embryonal carcinoma
              Non-gestational choriocarcinoma
              Mixed germ cell tumour of the ovary
         Monodermal teratomas and somatic-type tumours arising from a dermoid cyst
              Struma ovarii
              Ovarian carcinoid
              Neuroectodermal-type tumours
              Monodermal cystic teratoma
              Somatic neoplasms arising from teratomas
         Germ cell-sex cord-stromal tumours
              Gonadoblastoma
              Mixed germ cell-sex cord-stromal tumour, unclassified

    Miscellaneous tumours

              Rete cystadenoma, adenoma, and adenocarcinoma
              Wolffian tumour of the ovary
              Solid pseudopapillary tumour
              Small cell carcinoma of the ovary, hypercalcaemic type
              Wilms tumour

    Mesothelial tumours (see Tumours of the peritoneum)

    Tumour-like lesions

              Follicle cyst
              Corpus luteum cyst
              Large solitary luteinized follicle cyst
              Hyperreactio luteinalis
              Pregnancy luteoma
              Stromal hyperplasia and hyperthecosis
              Fibromatosis and massive oedema
              Leydig cell hyperplasia

    Metastases

              Metastases to the ovary

Endometriosis and related conditions

              Endometriosis and derived tumours

Tumours of the peritoneum

         Tumours of the peritoneum: Introduction

    Mesothelial tumours

              Adenomatoid tumour
              Well-differentiated papillary mesothelial tumour
              Mesothelioma

    Epithelial tumours

         Epithelial tumours of Mullerian type
              Serous borderline tumour of the peritoneum
              Low-grade serous carcinoma of the peritoneum
              High-grade serous carcinoma of the peritoneum

    Mesenchymal tumours specific to peritoneum

         Smooth muscle tumours
              Leiomyomatosis peritonealis disseminata
         Miscellaneous primary tumours
              Desmoid fibromatosis
              Calcifying fibrous tumour
              Extragastrointestinal stromal tumour
              Solitary fibrous tumour of the peritoneum
              Endometrioid stromal sarcoma of the peritoneum
              Desmoplastic small round cell tumour

    Tumour-like lesions

              Mesothelial hyperplasia
              Peritoneal inclusion cysts
              Transitional cell metaplasia
              Endosalpingiosis of the peritoneum
              Histiocytic nodule
              Ectopic decidua
              Splenosis
              Other tumour-like lesions of the peritoneum

    Metastases

              Carcinomas and sarcomas metastatic to the peritoneum
              Pseudomyxoma peritonei
              Gliomatosis

Tumours of the fallopian tube

         Tumours of the fallopian tube: Introduction

    Epithelial tumours

         Benign serous tumours
              Serous adenofibroma and papilloma of the fallopian tube
         Borderline serous tumours
              Serous borderline tumour of the fallopian tube
         Malignant epithelial tumours
              High-grade serous carcinoma of the fallopian tube
              Endometrioid carcinoma of the fallopian tube
              Carcinosarcoma of the fallopian tube

    Tumour-like lesions

              Paratubal cysts
              Tubal hyperplasia
              Tubo-ovarian abscess
              Salpingitis isthmica nodosa
              Metaplastic papillary lesion
              Placental site nodule occurring in the fallopian tube
              Mucinous metaplasia
              Endosalpingiosis of the fallopian tube

    Mixed epithelial and mesenchymal tumours

              Adenosarcoma of the fallopian tube

    Germ cell tumours

              Teratoma of the fallopian tube

Tumours of the broad ligament and other uterine ligaments

         Tumours of the broad ligament and other uterine ligaments: Introduction

    Mesenchymal and mixed tumours

              Leiomyoma of the broad ligament and other uterine ligaments
              Adenomyoma of the broad ligament and other uterine ligaments
              Adenosarcoma of the broad ligament and other uterine ligaments
              Leiomyosarcoma of the broad ligament and other uterine ligaments
              Other mesenchymal and mixed tumours of the broad ligament and other uterine ligaments

    Miscellaneous tumours

              Wolffian tumour of the broad ligament and other uterine ligaments
              Papillary cystadenoma
              Ependymoma

    Tumour-like lesions

              Adrenocortical remnants

Tumours of the uterine corpus

         Tumours of the uterine corpus: Introduction

    Endometrial epithelial tumours and precursors

         Precursor lesions
              Endometrial hyperplasia without atypia
              Endometrial atypical hyperplasia / endometrioid intraepithelial neoplasia
         Endometrial carcinomas
              Endometrioid carcinoma of the uterine corpus
              Serous carcinoma of the uterine corpus
              Clear cell carcinoma of the uterine corpus
              Undifferentiated and dedifferentiated carcinomas of the uterine corpus
              Mixed carcinoma of the uterine corpus
              Other endometrial carcinomas
              Carcinosarcoma of the uterine corpus

    Tumour-like lesions

         Tumour-like lesions
              Endometrial polyp
              Endometrial metaplasia
              Arias-Stella reaction of the uterine corpus

    Mesenchymal tumours of the uterus

         Smooth muscle tumours
              Uterine leiomyoma
              Intravenous leiomyomatosis
              Smooth muscle tumour of uncertain malignant potential of the uterine corpus
              Metastasizing leiomyoma
              Uterine leiomyosarcoma
         Endometrial stromal and related tumours
              Endometrial stromal nodule
              Low-grade endometrial stromal sarcoma
              High-grade endometrial stromal sarcoma
              Undifferentiated uterine sarcoma
         Miscellaneous mesenchymal tumours
              Uterine tumour resembling ovarian sex cord tumour
              Perivascular epithelioid cell tumour (PEComa)
              Inflammatory myofibroblastic tumour
              Other mesenchymal tumours of the uterus

    Mixed epithelial and mesenchymal tumours

         Mixed epithelial and mesenchymal tumours
              Adenomyoma of the uterine corpus
              Atypical polypoid adenomyoma
              Adenosarcoma of the uterine corpus

    Miscellaneous tumours

              Central primitive neuroectodermal tumour / CNS embryonal tumour
              Germ cell tumours of the uterine corpus

Gestational trophoblastic disease

         Gestational trophoblastic disease: Introduction

    Tumour-like lesions

         Non-neoplastic lesions
              Exaggerated placental site reaction
              Placental site nodule and plaque

    Abnormal (non-molar) villous lesions

    Molar pregnancies

         Molar pregnancies
              Partial hydatidiform mole
              Complete hydatidiform mole
              Invasive and metastatic hydatidiform moles

    Gestational trophoblastic neoplasms

         Gestational trophoblastic neoplasms
              Epithelioid trophoblastic tumour
              Placental site trophoblastic tumour
              Gestational choriocarcinoma
              Mixed trophoblastic tumour

Tumours of the uterine cervix

         Tumours of the uterine cervix: Introduction

    Squamous epithelial tumours

         Mimics of squamous precursor lesions
              Squamous metaplasia
              Atrophy of the uterine cervix
         Squamous cell tumours and precursors
              Condyloma acuminatum (see Tumours of the vulva)
              Squamous intraepithelial lesions of the uterine cervix
              Squamous cell carcinoma, HPV-associated, of the uterine cervix
              Squamous cell carcinoma, HPV-independent, of the uterine cervix
              Squamous cell carcinoma NOS of the uterine cervix

    Glandular tumours and precursors

         Benign glandular lesions
              Endocervical polyp
              Mullerian papilloma of the uterine cervix
              Nabothian cyst
              Tunnel clusters
              Microglandular hyperplasia
              Lobular endocervical glandular hyperplasia
              Diffuse laminar endocervical hyperplasia
              Mesonephric remnants and hyperplasia
              Arias-Stella reaction of the uterine cervix
              Endocervicosis of the uterine cervix
              Tuboendometrioid metaplasia
              Ectopic prostate tissue
         Adenocarcinomas
              Adenocarcinoma in situ, HPV-associated, of the uterine cervix
              Adenocarcinoma, HPV-associated, of the uterine cervix
              Adenocarcinoma in situ, HPV-independent, of the uterine cervix
              Adenocarcinoma, HPV-independent, gastric type, of the uterine cervix
              Adenocarcinoma, HPV-independent, clear cell type, of the uterine cervix
              Adenocarcinoma, HPV-independent, mesonephric type, of the uterine cervix
              Other adenocarcinomas of the uterine cervix

    Other epithelial tumours

              Carcinosarcoma of the uterine cervix
              Adenosquamous and mucoepidermoid carcinomas of the uterine cervix
              Adenoid basal carcinoma of the uterine cervix
              Carcinoma of the uterine cervix, unclassifiable

    Mixed epithelial and mesenchymal tumours

         Mixed epithelial and mesenchymal tumours
              Adenomyoma of the uterine cervix
              Adenosarcoma of the uterine cervix

    Germ cell tumours

         Germ cell tumours of the uterine cervix

Tumours of the vagina

         Tumours of the vagina: Introduction

    Epithelial tumours

         Benign squamous lesions
              Condyloma acuminatum (see Tumours of the vulva)
              Squamous papilloma of the vagina
              Atrophy of the vagina
              Tubulosquamous polyp
         Squamous cell tumours and precursors
              Squamous intraepithelial lesions of the vagina
              Squamous cell carcinoma, HPV-associated, of the vagina
              Squamous cell carcinoma, HPV-independent, of the vagina
              Squamous cell carcinoma NOS of the vagina
         Benign glandular lesions
              Villous adenoma
              Mullerian papilloma of the vagina
              Vaginal adenosis
              Endocervicosis of the vagina
              Cysts of the vagina
         Glandular tumours
              Adenocarcinoma, HPV-associated, of the vagina
              Endometrioid carcinoma of the vagina
              Clear cell carcinoma of the vagina
              Mucinous carcinoma, gastric type, of the vagina
              Mucinous carcinoma, intestinal type, of the vagina
              Mesonephric adenocarcinoma of the vagina
              Carcinosarcoma of the vagina
         Other epithelial tumours
              Mixed tumour of the vagina
              Adenocarcinoma of Skene gland origin
              Adenosquamous carcinoma of the vagina
              Adenoid basal carcinoma of the vagina

    Mixed epithelial and mesenchymal tumours

              Adenosarcoma of the vagina

    Miscellaneous tumours

              Germ cell tumours of the vagina

Tumours of the vulva

         Tumours of the vulva: Introduction

    Epithelial tumours

         Benign squamous lesions
              Seborrhoeic keratosis
              Condyloma acuminatum
         Squamous cell tumours and precursors
              Squamous intraepithelial lesions, HPV-associated, of the vulva
              Vulvar intraepithelial neoplasia, HPV-independent
              Squamous cell carcinoma, HPV-associated, of the vulva
              Squamous cell carcinoma, HPV-independent, of the vulva
              Squamous cell carcinoma NOS of the vulva
              Basal cell carcinoma
         Glandular tumours and cysts
              Mammary-type glandular lesions
                   Papillary hidradenoma
                   Chondroid syringoma
                   Fibroadenoma
                   Phyllodes tumour
                   Adenocarcinoma of mammary gland type
              Bartholin gland lesions
                   Bartholin gland cyst
                   Bartholin gland hyperplasia, adenoma, and adenomyoma
                   Bartholin gland carcinomas
              Other cysts of the vulva
         Adenocarcinomas of other types
              Paget disease
              Carcinomas of sweat gland origin
              Adenocarcinoma of intestinal type

    Germ cell tumours

              Germ cell tumours of the vulva

Neuroendocrine neoplasia

         Neuroendocrine neoplasia: Introduction
         Neuroendocrine tumour
              Neuroendocrine tumour
         Neuroendocrine carcinoma
              Small cell neuroendocrine carcinoma
              Large cell neuroendocrine carcinoma
         Mixed neuroendocrine-non-neuroendocrine neoplasms
              Carcinoma admixed with neuroendocrine carcinoma

Haematolymphoid proliferations and neoplasia

         Haematolymphoid proliferations and neoplasia: Introduction
         Reactive lymphoid hyperplasia
              Florid reactive lymphoid hyperplasia
         Lymphomas
              Diffuse large B-cell lymphoma
              Extranodal marginal zone lymphoma
              Follicular lymphoma
              Burkitt lymphoma
         Myeloid leukaemia
              Myeloid sarcoma

Mesenchymal tumours of the lower genital tract

    Mesenchymal tumours of the lower genital tract: Introduction

         Adipocytic tumours
              Lipoma
              Lipoblastoma-like tumour of the vulva
              Liposarcoma
         Fibroblastic and myofibroblastic tumours
              Postoperative spindle cell nodule
              Fibroepithelial stromal polyp
              Prepubertal fibroma
              Superficial myofibroblastoma
              Myofibroblastoma
              Cellular angiofibroma
              Angiomyofibroblastoma
              Solitary fibrous tumour of the lower genital tract
              Dermatofibrosarcoma protuberans
              NTRK-rearranged spindle cell neoplasm (emerging)
         Vascular tumours
              Kaposi sarcoma
              Angiosarcoma
         Smooth muscle tumours
              Leiomyoma of the lower genital tract
              Smooth muscle tumour of uncertain malignant potential of the lower genital tract
              Leiomyosarcoma of the lower genital tract
         Skeletal muscle tumours
              Rhabdomyoma
              Rhabdomyosarcoma
         Peripheral nerve sheath tumours
              Benign peripheral nerve sheath tumours
              Granular cell tumour
         Tumours of uncertain differentiation
              Superficial angiomyxoma
              Deep (aggressive) angiomyxoma
              Epithelioid sarcoma
              Alveolar soft part sarcoma
         Undifferentiated small round cell sarcomas
              Ewing sarcoma

Melanocytic lesions

         Naevi
              Acquired melanocytic naevus
              Congenital melanocytic naevus
              Blue naevus
              Atypical melanocytic naevus of genital type
              Dysplastic melanocytic naevus
         Melanoma
              Mucosal melanoma

Metastasis

              Metastasis to the lower female genital tract

Genetic tumour syndromes of the female genital tract

              BRCA1/2-associated hereditary breast and ovarian cancer syndrome
              Lynch syndrome
              Cowden syndrome
              Li-Fraumeni syndrome
              Peutz-Jeghers syndrome
              Ataxia-telangiectasia
              Carney complex
              DICER1 syndrome
              Ovarian dysgenesis
              Von Hippel-Lindau syndrome
              Hereditary leiomyomatosis and renal cell carcinoma
              Other genetic tumour syndromes of the female genital tract