Skin Tumours

Keratinocytic/epidermal tumours

            Introduction

      Carcinoma precursors and benign simulants

             Premalignant keratoses
                  Actinic keratosis
                  Arsenical keratosis
                  PUVA keratosis
            Verrucae
                  Verruca vulgaris
                  Verruca plantaris
                  Verruca plana
            Benign acanthomas/keratoses
                  Seborrhoeic keratosis
                  Solar lentigo
                  Lichenoid keratosis (discuss in EB)
                  Clear cell acanthoma
                  Large cell acanthoma
                  Warty dyskeratoma
                  Other benign keratoses

      Carcinomas

            Basal cell carcinomas
                  Superficial basal cell carcinoma
                  Nodular basal cell carcinoma
                  Micronodular basal cell carcinoma
                  Infiltrating basal cell carcinoma
                  Sclerosing/morphoeic basal cell carcinoma
                  Basosquamous carcinoma
                  Basal cell carcinoma with sarcomatoid differentiation
                  Basal cell carcinoma with adnexal differentiation
                  Fibroepithelial basal cell carcinoma
            Squamous cell carcinomas
                  Squamous cell carcinoma in situ (Bowen disease)
                  Keratoacanthoma
                  Verrucous carcinoma
                  Squamous cell carcinoma (expand)

      Neuroendocrine neoplasms

            Neuroendocrine carcinomas
                  Merkel cell carcinoma

Melanocytic tumours

                  Introduction
                  Genomic landscape of melanoma

     Melanocytic tumours in intermittently sun-exposed skin

             Naevi
                  Junctional, compound, and dermal naevi
                  Simple lentigo and lentiginous melanocytic naevus
                  Dysplastic naevus
                  Naevus spilus
                  Special-site naevi (of the breast, axilla, scalp, and ear)
                  Halo naevus
                  Meyerson naevus
                  Recurrent naevus
                  Deep penetrating naevus and melanocytoma
                  Pigmented epithelioid melanocytoma
                  BAP-inactivated naevus
                  Combined naevus
             Melanoma
                  Low-CSD melanoma (superficial spreading melanoma)               

     Melanocytic tumours in chronically sun-exposed skin

             Melanoma
                  Lentigo maligna melanoma
                  Desmoplastic melanoma

     Spitz tumours

                  Pigmented spindle cell naevus (Reed naevus)
                  Spitz naevus
                  Atypical Spitz tumour
                  Malignant Spitz tumour (Spitz melanoma)

     Melanocytic tumours in acral skin

              Naevi
                  Acral naevus
              Melanoma
                  Acral melanoma

     Genital and mucosal melanocytic tumours

              Naevi
                  Melanosis
                  Genital naevus
              Melanomas
                  Mucosal melanomas (genital, oral, sinonasal)

    Melanocytic tumours arising in blue naevus

             Naevi
                  Naevus of Ito and naevus of Ota
                  Mongolian spot
                  Blue naevus and cellular blue naevus
             Melanomas
                  Melanoma arising in blue naevus

    Melanocytic tumours arising in congenital naevi

         Naevi
              Congenital melanocytic naevus
              Proliferative nodules in congenital melanocytic naevus
         Melanomas
              Melanoma arising in giant congenital naevus

    Ocular and CNS melanocytic tumours

              Conjunctival naevus (could split)
              Conjunctival melanocytic intraepithelial neoplasia/primary acquired melanosis
              Conjunctival melanoma
              Melanocytoma
              Uveal melanoma
              CNS melanoma

    Nodular, naevoid, and metastatic melanomas

         Melanomas
              Nodular melanoma
              Naevoid melanoma
              Dermal melanoma
              Metastatic melanoma in the skin

Appendageal tumours

              Introduction

    Tumours with apocrine and eccrine differentiation

         Benign tumours
              Hidrocystoma/cystadenoma
              Syringoma
              Poroma
              Syringofibroadenoma
              Hidradenoma
              Spiradenoma
              Cylindroma
              Tubular adenoma
              Syringocystadenoma papilliferum
              Mixed tumour
              Myoepithelioma
         Malignant tumours
              Adnexal adenocarcinoma, NOS
              Microcystic adnexal carcinoma
              Porocarcinoma
              NUT carcinoma
              Malignant neoplasms arising from spiradenoma, cylindroma, or spiradenocylindroma
              Malignant mixed tumour
              Hidradenocarcinoma
              Mucinous carcinoma
              Endocrine mucin-producing sweat gland carcinoma
              Digital papillary adenocarcinoma
              Adenoid cystic carcinoma
              Apocrine carcinoma
              Adenosquamous carcinoma (may delete?)
              Squamoid eccrine ductal carcinoma
              Syringocystadenocarcinoma papilliferum
              Secretory carcinoma
              Cribriform carcinoma
              Signet-ring cell/histiocytoid carcinoma

    Tumours with follicular differentiation

         Benign tumours
              Trichoblastoma
              Pilomatricoma
              Trichilemmoma
              Trichofolliculoma
              Pilar sheath acanthoma
              Tumour of the follicular infundibulum
              Melanocytic matricoma
              Spindle cell–predominant trichodiscoma
         Malignant tumours
              Pilomatrical carcinoma
              Proliferating trichilemmal tumour
              Trichoblastic carcinoma/carcinosarcoma
              Trichilemmal carcinoma

    Tumours with sebaceous differentiation

         Benign tumours
              Sebaceoma
              Sebaceous adenoma
         Malignant tumours
              Sebaceous carcinoma

    Site-specific tumours

         Benign tumours
              Hidradenoma papilliferum
              Fibroadenoma and phyllodes tumour of anogenital mammary-like glands
         Malignant tumours
              Mammary Paget disease
              Extramammary Paget disease
              Adenocarcinoma of anogenital mammary-like glands

Nail bed tumours

    Nail bed epithelial tumours

              Onychopapilloma
              Onychomatricoma (this is a fibroepithelial lesion)
              Subugual keratoacathoma
              Squamous cell carcinoma of the nail

    Other tumours of the nail bed

              Ungual fibrokeratoma and fibroma

Tumours of haematopoietic and lymphoid origin

              Introduction

    Myeloid proliferations and neoplasms

         Mastocytosis
              Cutaneous mastocytosis
              Systemic mastocytosis
              Mast cell sarcoma
         Secondary cutaneous involvement in myeloid neoplasms
              Cutaneous involvement in myeloid leukaemia - Rename: Myeloid sarcoma?

    Histiocytic/Dendritic cell neoplasms

         Plasmacytoid dendritic cell neoplasms
              Mature plasmacytoid dendritic cell proliferation
              Blastic plasmacytoid dendritic cell neoplasm
         Langerhans cell neoplasms
              Langerhans cell histiocytosis
         Histiocytic neoplasms
              Juvenile xanthogranuloma
              Erdheim-Chester disease
              Rosai-Dorfman Disease
              ALK related histiocytosis
              Reticulohistiocytosis
              Histiocytic sarcoma
         Interdigitating dendritic cell neoplasms
              Indeterminate dendritic cell tumour

    B-cell lymphoproliferative disorders and neoplasms

              Reactive B-cell rich lymphoid proliferations

         Primary cutaneous mature B cell neoplasms
              B-cell pseudolymphoma
              Primary cutaneous marginal zone (MALT) lymphoma
              Primary cutaneous follicle centre lymphoma
              Primary cutaneous diffuse large B-cell lymphoma, leg type
              Intravascular large B-cell lymphoma
              EBV-positive mucocutaneous ulcer
         Cutaneous involvement in primarily extracutaneous B-cell lymphomas and leukaemias
              Mantle cell lymphoma
              Burkitt lymphoma
              Chronic lymphocytic leukaemia/small lymphocytic lymphoma
              B-lymphoblastic leukaemia/lymphoma
              Secondary lymphomatoid granulomatosis

    T-cell lymphoproliferative disorders and neoplasms

              Reactive T-cell and NK-cell rich lymphoid proliferations

         Primary cutaneous T cell disorders
              Primary cutaneous CD+ small or medium T-cell lymphoproliferative disorder
              Mycosis fungoides
              Primary cutaneous CD+ T-cell lymphoproliferative disorder: Lymphomatoid papulosis
              ALCL
              Primary cutaneous CD+ T-cell lymphoproliferative disorder: Primary cutaneous anaplastic large cell lymphoma
              Subcutaneous panniculitis-like T-cell lymphoma
              Primary cutaneous gamma/delta T-cell lymphoma
              Primary cutaneous CD-positive aggressive epidermotropic cytotoxic T-cell lymphoma (provisional)
              Primary cutaneous acral CD-positive T-cell lymphoma
              Primary cutaneous T-cell lymphoma, NOS
              Sezary syndrome
         EBV-positive lymphoproliferative diseases of childhood
              Severe mosquito bite allergy
              Hydroa vacciniforme-like lymphoproliferative disorder
         Secondary cutaneous involvement in T-cell lymphomas and leukaemias
              Systemic anaplastic large cell lymphoma
              Angioimmunoblastic T-cell lymphoma
              T-cell prolymphocytic leukaemia
              T-lymphoblastic leukaemia/lymphoma

    NK-cell neoplasms

              Extranodal NK/T-cell lymphoma
              Others

    Others

              Adult T cell leukaemia/lymphoma
              Primary immunodeficiency-associated lymphoproliferative disorders

Soft tissue tumours

              Introduction

    Adipocytic tumours

              Naevus lipomatosus superficialis
              Lipoma
              Angiolipoma
              Spindle cell/pleomorphic lipoma
              Atypical lipomatous tumour
              Pleomorphic liposarcoma

    Fibroblastic, myofibroblastic, and fibrohistiocytic tumours

         Benign neoplasms
              Fibromas
              Fibrous papule family
              Fibroblastic connective tissue nevus
              Fibroosseous pseudotumor of digits and myositis ossificans
              Dermatofibroma (fibrous histiocytoma) and variants
              Superficial fibromatosis
              Inclusion body fibromatosis
              Plexiform fibrohistiocytic tumour
              Superficial acral fibromyxoma
              Cutaneous myxoma
              Dermatomyofibroma
              Multinucleate angiohistiocytoma
              Plaque-like CD+ dermal fibroma
              Nodular fasciitis
         Malignant neoplasms
              Dermatofibrosarcoma protuberans and variants
              Myxoinflammatory fibroblastic sarcoma
              EWSR-SMAD rearranged fibroblastic tumour (provisional)

    Vascular tumours

         Haemangiomas
              Cherry haemangioma
              Sinusoidal haemangioma
              Microvenular haemangioma
              Hobnail haemangioma
              Glomeruloid haemangioma
              Papillary haemangioma
              Spindle cell haemangioma
              Epithelioid haemangioma
              Tufted haemangioma
              Angiokeratoma
              Infantile haemangioma
              Congenital non-progressive haemangiomas: rapidly involuting congenital haemangioma and non-involuting congenital haemangioma
              Lobular capillary haemangioma
              Poikilodermatous plaque-like haemangioma
              Acquired elastic haemangioma
              Verrucous venous malformation
              Arteriovenous malformation
         Other benign vascular tumours
              Lymphangioma (superficial lymphatic malformation)
              Cutaneous epithelioid angiomatous nodule
              Atypical vascular lesion
              Haemangioendothelioma family
              Kaposi sarcoma
         Malignant vascular sarcomas
              Cutaneous angiosarcoma

    Pericytic tumours

         Benign neoplasms
              Glomus tumour and variants
              Myopericytoma (including myofibroma and myofibromatosis)
              Angioleiomyoma

    Smooth muscle tumours 

         Benign neoplasms
              Smooth muscle hamartoma
              Cutaneous leiomyomas and variants
              EBV-associated smooth muscle tumour
         Malignant neoplasms
              Cutaneous leiomyosarcoma (atypical smooth muscle tumour)

    Neural tumours

         Benign neoplasms
              Neurofibroma and subtypes
              Solitary circumscribed neuroma
              Dermal nerve sheath myxoma
              Perineurioma
              Granular cell tumour
              Schwannoma
              Hybrid nerve sheath tumours
              Dermal hyperneury/Epithelial sheath neuroma
         Malignant neoplasms
              Malignant peripheral nerve sheath tumour

    Tumours of uncertain differentiation

         Benign neoplasms
              Cellular neurothekeoma
              Epithelioid fibrous histiocytoma
              PEComa
              Angiomatoid fibrous histiocytoma
              Lipofibromatosis-like neural tumour / NTRK-rearranged spindle cell neoplasm (provisional)
              Atypical fibroxanthoma and subtypes
              Non-neural granular cell tumour
         Malignant neoplasms
              Pleomorphic dermal sarcoma
              Myxofibrosarcoma
              Epithelioid sarcoma
              Superficial CD+ fibroblastic tumour / PRDM-rearranged soft tissue tumour
              TRIM melanocytoma
              Dermal clear cell sarcoma
              Ewing sarcoma
              Pseudomyogenic haemangioendothelioma

Metastases to skin

              Metastases to skin

Inherited tumour syndromes associated with skin malignancies

              Introduction
              Familial melanoma
              BAP tumour predisposition syndrome
              Xeroderma pigmentosum
              Naevoid basal cell carcinoma syndrome (Gorlin syndrome)
              Carney complex
              Muir-Torre syndrome
              Brooke-Spiegler and related syndromes